1. Our Legacy of Innovation

Founded by the visionary late Shri Vimal Kumar, Harshul Ayur Pharma has been pioneering Ayurvedic Reaserach & Development in Ramnagar, Uttarakhand— continuing a legacy of combining ancient knowledge with modern science under the stewardship of his wife, Shrimati Sarita Agarwal.
On the footsteps laid by late Shri Vimal Kumar, our company has remained committed to delivering authentic, effective, and affordable healthcare solutions for all new-age problems arising from today’s demanding lifestyles. Each of our formulations is the result of deep research, backed by modern scientific validation, and has earned the trust of countless patients across the country who have experienced positive results.

2. SAVLIV® - A Patented Herbal Breakthrough

SAVLIV is a patented Ayurvedic formulation as ‘A Synergistic and Non Toxic Combination for treating Liver Disorders’—a testament to its uniqueness and clinical promise. A traditional herbo-mineral recipe, invented by Late Shri Vimal Kumar, is a revolutionary invention in this category and a fast-acting powerful hepatic stimulant which increases the functional capacity of liver, accelerates cellular metabolic activity and promotes liver cells regeneration.

Late Shri Vimal Kumar with eminent scientists in India

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Clinical Trials at Gurukul Kangri Vishvavidylaya (Haridwar) – Year 1994

  • Total patients – 50, period of administration – 04 Weeks
Sex Age Total
1–10 Yrs 10–35 Yrs 35–60 Yrs
Male 5 20 5 30
Female 4 13 3 20
Total 50

  • Diagnosis and symptoms of patients

Symptoms & Prevalent Signs No. of Patients
Nausea & vomiting 45
Anorexia 49
Fever 35
Abdominal distention 20
Edema 05
Jaundice 15
Hepatic Enlargement (Fatty Liver) 35

Results:-

  • Administration of SAVLIV caused the cessation of Nausea and vomiting in all cases with the very first doze.
  • Patients with Jaundice showed very significant recovery from 07 to 11 days.
  • Significant benefit to Patients with hepatic enlargement (Fatty Liver). Out of 35, 31 (88.5%) patients showed an average ½ CM reduction of enlarged liver size every third day.
  •  In case of Hepatic disorders, SAVLIV produced very good improvement in 50% patients and good to moderate improvement in 45% patients in the given period of administration.
  • SAVLIV was accepted well by patients of all age groups and sex without any toxicity.


Conclusion:-


  • Due to wide acceptability, promptness in eliciting response, easy administration and high percentage of satisfactory improvement, SAVLIV to be recommended to the patients suffering from hepatic disorders. 
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Publication of research paper on SAVLIV with title ‘Chemistry of Traditional Recipes used in Hepatic Disorders’ in medical Journal TOHO (The East), Tokyo Japan – Year 1994

Observation on formulation:-

  • Presence of Sodium, Potassium, Calcium, Magnesium, Phosphorus, Chloride, Sulphate, Iron and Citric acid in the formulation. Because of resence of these minerals, the medicine should therefore find high level of acceptance for patients of hepatic disorder.
  • The minerals found in the formulation are essential for the proper growth of the body, and form a constituent of all extracellular fluids and various digestive juices.
  • The constituents of the herbo-mineral recipe have been shownto be primarily responsible for various physiological andmetabolic effects and significant hepato-protective activity.
  • This traditional drug has proved as a boon to the patients withliver ailments, either viral or toxicity of antibiotic, alcohol andother synthetic drugs.
  • SAVLIV has an advantage of using substances with which thehuman system is already familiar, hence has a high level ofacceptability by the human body.
  • This traditional recipe may provide a new impetus toresearchers and help to find new product to combat deadlyhepatic viruses responsible to set untimely.


Suggestions :- Along with Liver ailments, the recipe may also be used-

  • To keep the electrolytic balance in dehydration.
  • In Anemia, Jaundice, due to its ingredients effective and essential in the disorders of Haemopoietic system.
  • In viral fever, Dengue fever (the recovery was very fast); probably it provides an impetus to the immune system of the body.
  • Due to its effect on promoting the immune system of the body, it may be an adjunct to the patients of AIDS, Tuberculosis and Cancer. Thus an indirect help to combat these diseases.
  • As an adjunct during chemotherapy, antibiotics etc to safe guard the liver against toxicity of chemical based synthetic drugs.
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Scientific validation of safety, protective and curative efficacy of SAVLIV – A Pre-Clinical study at Sri Ram Chandra University Chennai – Years 2012 -

Objectives

  • Standardization of SAVLIV.
  • To validate long term toxicity potential of SAVLIV.
  • To validate the efficacy of SAVLIV.


Research model – Male & Female Wistar Rats.

Observation periods – 28 days and 90 days.


Findings


Standardization :-

  • Presence of phenolic compounds, tannins, glycosides, sugars, alkaloids and flavones in SAVLIV.
  • SAVLIV was found to contain 440.74±18.11 µg/ml of total phenol, 58.57±4.03 µg/ml of flavonoid and 235.37±13.70 µg/ml of tannin.
  • SAVLIV was found to contain Vitamin C (1.34±0.04 mg/ml) and Citric acid (6.4 ±0.54 mg/ml).
  • HPTLC finger printing of SAVLIV showed 11 peaks in the tested chromatographic condition.
  • SAVLIV was found to be potent scavenger of DPPH, super oxide, lipid peroxide, nitric oxide and H2O2 radicals. SAVLIV is free from heavy metals such as lead [Pb], Cadmium [Cd], Mercury [Hg] and Arsenic [As].
  • SAVLIV was found to be stable for a period of three months even at accelerated stability conditions (40°C±2°C 75%± 5% RH).


Validation of Oral Toxicity:-

  • The LD50 of SAVLIV was greater than 2000mg/kg b.wt. Hence, SAVLIV was found to be safe when administered once orally at a dose of 2000mg/kg b.wt. in mice.
  • Low-Observed-Adverse-Effect-Level (LOAEL) of SAVLIV was found to be 1000mg/kg/day and No-Observed-Adverse Effect-Level (NOAEL) of SAVLIV was 500 mg/kg/day, when administered orally for a period of 28 days in rats.
  • Low-observed-Adverse-Effect-Level (LOAEL) of SAVLIV was found to be 500 mg/kg/day and No-Observed-Adverse Effect-Level (NOAEL) of SAVLIV was 250 mg/kg/day, when administered orally for a period of 90 days in rats.


Validation of Efficacy:-

  • Hepatoprotective effect of SAVLIV was investigated using chemically (Paracetamol, Ethanol and CCl4) induced hepatotoxicity mice model.
  • SAVLIV pretreatment at 25mg, 50mg and 100 mg/kg prevented the hepatotoxic damage induced chemicals in dose dependent manner which was evidenced in reduced level of hepatobiliary enzymes.
  • The results further confirm the hepatoprotective effect of SAVLIV. It is mainly due to the presence of high content of antioxidant rich ingredients especially total phenols, Vitamin C and citric acid in SAVLIV formulation.
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